Drug interactions
Amoxapine + Diphenoxylate-atropine
Severity: Moderate
Amoxapine and Diphenoxylate-atropine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amoxapine has anticholinergic and sedative effects, and atropine adds antimuscarinic activity while diphenoxylate adds opioid sedation. The combination may worsen constipation and risk ileus, urinary retention, confusion and drowsiness.
What this interaction means in plain words
Amoxapine and Diphenoxylate-atropine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic and CNS depressant effects.
What to do
Monitor for constipation, urinary retention, sedation and confusion, and use the lowest effective doses for the shortest time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diphenoxylate-atropine
- Diphenoxylate-atropine + Isocarboxazid Contraindicated
- Diphenoxylate-atropine + Phenelzine Contraindicated
- Diphenoxylate-atropine + Tranylcypromine Contraindicated
- Alfentanil + Diphenoxylate-atropine Major
- Alvimopan + Diphenoxylate-atropine Major
- Amitriptyline + Diphenoxylate-atropine Major
Frequently asked questions
Can I take Amoxapine with Diphenoxylate-atropine?
MediHelp rates the interaction as moderate. Amoxapine and Diphenoxylate-atropine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amoxapine has anticholinergic and sedative effects, and atropine adds antimuscarinic activity while diphenoxylate adds opioid sedation. The combination may worsen constipation and risk ileus, urinary retention, confusion and drowsiness.
How serious is the interaction between Amoxapine and Diphenoxylate-atropine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for constipation, urinary retention, sedation and confusion, and use the lowest effective doses for the shortest time.
What other medicines interact with Diphenoxylate-atropine?
MediHelp also lists interactions of Diphenoxylate-atropine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Diphenoxylate-atropine page.
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