Drug interactions
Amoxapine + Fesoterodine
Severity: Moderate
Amoxapine and Fesoterodine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amoxapine has anticholinergic activity, so combination with fesoterodine increases the risk of dry mouth, constipation, urinary retention, blurred vision and confusion. Older patients are especially vulnerable.
What this interaction means in plain words
Amoxapine and Fesoterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic effects.
What to do
Monitor for anticholinergic toxicity and cognitive effects, and lower doses or choose a less anticholinergic antidepressant if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fesoterodine
Frequently asked questions
Can I take Amoxapine with Fesoterodine?
MediHelp rates the interaction as moderate. Amoxapine and Fesoterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amoxapine has anticholinergic activity, so combination with fesoterodine increases the risk of dry mouth, constipation, urinary retention, blurred vision and confusion. Older patients are especially vulnerable.
How serious is the interaction between Amoxapine and Fesoterodine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity and cognitive effects, and lower doses or choose a less anticholinergic antidepressant if needed.
What other medicines interact with Fesoterodine?
MediHelp also lists interactions of Fesoterodine with, for example, Bethanechol, Clozapine, Levoketoconazole. The full list is on the Fesoterodine page.
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