Drug interactions
Bethanechol + Fesoterodine
Severity: Major
Bethanechol and Fesoterodine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fesoterodine is converted to an active antimuscarinic metabolite that opposes bethanechol's bladder-stimulating effect. The drugs have opposing actions and negate each other.
What this interaction means in plain words
Bethanechol and Fesoterodine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bethanechol belongs to Gastrointestinal Tract; Fesoterodine belongs to Genitourinary.
Why it happens
Competitive muscarinic antagonism by the active metabolite of fesoterodine against bethanechol.
What to do
Avoid combining; reassess the underlying bladder dysfunction and select one therapy.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Bethanechol
- Bethanechol + Darifenacin Major
- Bethanechol + Oxybutynin Major
- Bethanechol + Physostigmine Major
- Amifampridine + Bethanechol Moderate
- Amitriptyline + Bethanechol Moderate
- Amoxapine + Bethanechol Moderate
Other interactions of Fesoterodine
Frequently asked questions
Can I take Bethanechol with Fesoterodine?
MediHelp rates the interaction as major. Bethanechol and Fesoterodine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fesoterodine is converted to an active antimuscarinic metabolite that opposes bethanechol's bladder-stimulating effect. The drugs have opposing actions and negate each other.
How serious is the interaction between Bethanechol and Fesoterodine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining; reassess the underlying bladder dysfunction and select one therapy.
What other medicines interact with Bethanechol?
MediHelp also lists interactions of Bethanechol with, for example, Darifenacin, Oxybutynin, Physostigmine. The full list is on the Bethanechol page.
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