Drug interactions
Amoxapine + Fluticasone-salmeterol
Severity: Major
Amoxapine and Fluticasone-salmeterol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic-type antidepressants can potentiate the cardiovascular effects of beta-agonists such as salmeterol. This may cause tachycardia, palpitations, QT prolongation and arrhythmia, and salmeterol labeling advises caution within and shortly after tricyclic therapy.
What this interaction means in plain words
Amoxapine and Fluticasone-salmeterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive QT-prolonging and adrenergic effects, with tricyclic noradrenaline reuptake inhibition enhancing the vascular response to beta-agonists.
What to do
Use with ECG and heart rate monitoring and consider an alternative to the tricyclic or the LABA in patients with cardiac risk. Check potassium in at-risk patients.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fluticasone-salmeterol
- Darunavir + Fluticasone-salmeterol Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Fluticasone-salmeterol Contraindicated
- Fluticasone-salmeterol + Fosamprenavir Contraindicated
- Fluticasone-salmeterol + Indinavir Contraindicated
- Fluticasone-salmeterol + Lopinavir Contraindicated
- Fluticasone-salmeterol + Nelfinavir Contraindicated
Frequently asked questions
Can I take Amoxapine with Fluticasone-salmeterol?
MediHelp rates the interaction as major. Amoxapine and Fluticasone-salmeterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tricyclic-type antidepressants can potentiate the cardiovascular effects of beta-agonists such as salmeterol. This may cause tachycardia, palpitations, QT prolongation and arrhythmia, and salmeterol labeling advises caution within and shortly after tricyclic therapy.
How serious is the interaction between Amoxapine and Fluticasone-salmeterol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use with ECG and heart rate monitoring and consider an alternative to the tricyclic or the LABA in patients with cardiac risk. Check potassium in at-risk patients.
What other medicines interact with Fluticasone-salmeterol?
MediHelp also lists interactions of Fluticasone-salmeterol with, for example, Darunavir, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Fosamprenavir. The full list is on the Fluticasone-salmeterol page.
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