Drug interactions
Amoxapine + Foscarnet
Severity: Moderate
Amoxapine and Foscarnet: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Foscarnet has been associated with QT prolongation and electrolyte disturbances such as low calcium, magnesium and potassium. Amoxapine can also prolong the QT interval, especially in overdose. Together they may raise the risk of torsades de pointes.
What this interaction means in plain words
Amoxapine and Foscarnet can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation, with foscarnet-induced electrolyte depletion increasing arrhythmia susceptibility.
What to do
Obtain a baseline ECG and monitor it during therapy. Check and correct potassium, magnesium and calcium regularly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Foscarnet
- Cidofovir + Foscarnet Contraindicated
- Foscarnet + Pimozide Contraindicated
- Foscarnet + Thioridazine Contraindicated
- Foscarnet + Vandetanib Contraindicated
- Adagrasib + Foscarnet Major
- Adefovir + Foscarnet Major
Frequently asked questions
Can I take Amoxapine with Foscarnet?
MediHelp rates the interaction as moderate. Amoxapine and Foscarnet can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Foscarnet has been associated with QT prolongation and electrolyte disturbances such as low calcium, magnesium and potassium. Amoxapine can also prolong the QT interval, especially in overdose. Together they may raise the risk of torsades de pointes.
How serious is the interaction between Amoxapine and Foscarnet?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor it during therapy. Check and correct potassium, magnesium and calcium regularly.
What other medicines interact with Foscarnet?
MediHelp also lists interactions of Foscarnet with, for example, Cidofovir, Pimozide, Thioridazine. The full list is on the Foscarnet page.
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