Drug interactions
Cidofovir + Foscarnet
Severity: Contraindicated
Cidofovir and Foscarnet: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents are clearly nephrotoxic, and combined use markedly increases the risk of acute kidney injury. Cidofovir labeling contraindicates use with other nephrotoxic agents and requires a washout period after them.
What this interaction means in plain words
Cidofovir and Foscarnet are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Cidofovir belongs to Anti Virals; Foscarnet belongs to Anti Virals.
Why it happens
Additive direct renal tubular toxicity.
What to do
Do not co-administer; choose an alternative antiviral strategy and, where sequential use is needed, allow an adequate washout with renal function monitoring.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Cidofovir
- Amikacin + Cidofovir Contraindicated
- Amphotericin b deoxycholate + Cidofovir Contraindicated
- Amphotericin b + Cidofovir Contraindicated
- Bacitracin + Cidofovir Contraindicated
- Capreomycin + Cidofovir Contraindicated
- Cephaloridine + Cidofovir Contraindicated
Other interactions of Foscarnet
- Foscarnet + Pimozide Contraindicated
- Foscarnet + Thioridazine Contraindicated
- Foscarnet + Vandetanib Contraindicated
- Adagrasib + Foscarnet Major
- Adefovir + Foscarnet Major
- Alfuzosin + Foscarnet Major
Frequently asked questions
Can I take Cidofovir with Foscarnet?
MediHelp rates the interaction as contraindicated. Cidofovir and Foscarnet are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both agents are clearly nephrotoxic, and combined use markedly increases the risk of acute kidney injury. Cidofovir labeling contraindicates use with other nephrotoxic agents and requires a washout period after them.
How serious is the interaction between Cidofovir and Foscarnet?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; choose an alternative antiviral strategy and, where sequential use is needed, allow an adequate washout with renal function monitoring.
What other medicines interact with Cidofovir?
MediHelp also lists interactions of Cidofovir with, for example, Amikacin, Amphotericin b deoxycholate, Amphotericin b. The full list is on the Cidofovir page.
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