Drug interactions
Amoxapine + Frovatriptan
Severity: Moderate
Amoxapine and Frovatriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amoxapine inhibits serotonin and norepinephrine reuptake and may add to the serotonergic effect of frovatriptan. Serotonin syndrome is a theoretical risk and reports are rare.
What this interaction means in plain words
Amoxapine and Frovatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic effects from reuptake inhibition and triptan 5-HT1B/1D agonism.
What to do
Monitor for serotonin syndrome symptoms when starting or titrating either drug, and stop both if it occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Frovatriptan
- Almotriptan + Frovatriptan Contraindicated
- Dihydroergotamine intranasal + Frovatriptan Contraindicated
- Dihydroergotamine + Frovatriptan Contraindicated
- Eletriptan + Frovatriptan Contraindicated
- Ergoloid mesylates + Frovatriptan Contraindicated
- Ergotamine + Frovatriptan Contraindicated
Frequently asked questions
Can I take Amoxapine with Frovatriptan?
MediHelp rates the interaction as moderate. Amoxapine and Frovatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amoxapine inhibits serotonin and norepinephrine reuptake and may add to the serotonergic effect of frovatriptan. Serotonin syndrome is a theoretical risk and reports are rare.
How serious is the interaction between Amoxapine and Frovatriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for serotonin syndrome symptoms when starting or titrating either drug, and stop both if it occurs.
What other medicines interact with Frovatriptan?
MediHelp also lists interactions of Frovatriptan with, for example, Almotriptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Frovatriptan page.
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