Drug interactions
Amoxapine + Galantamine
Severity: Moderate
Amoxapine and Galantamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amoxapine has anticholinergic properties that oppose the cholinergic effect of galantamine, so the benefit of the cholinesterase inhibitor on cognition may be reduced. Galantamine may also add to bradycardia or other cardiac effects in susceptible patients.
What this interaction means in plain words
Amoxapine and Galantamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism between acetylcholinesterase inhibition and muscarinic receptor blockade by amoxapine.
What to do
Where possible choose an antidepressant with minimal anticholinergic activity in patients taking galantamine. If combined, monitor cognitive response and heart rate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Galantamine
- Galantamine + Memantine-donepezil Major
- Galantamine + Physostigmine Major
- Galantamine + Ponesimod Major
- Galantamine + Rivastigmine Major
- Amifampridine + Galantamine Moderate
- Amiodarone + Galantamine Moderate
Frequently asked questions
Can I take Amoxapine with Galantamine?
MediHelp rates the interaction as moderate. Amoxapine and Galantamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amoxapine has anticholinergic properties that oppose the cholinergic effect of galantamine, so the benefit of the cholinesterase inhibitor on cognition may be reduced. Galantamine may also add to bradycardia or other cardiac effects in susceptible patients.
How serious is the interaction between Amoxapine and Galantamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where possible choose an antidepressant with minimal anticholinergic activity in patients taking galantamine. If combined, monitor cognitive response and heart rate.
What other medicines interact with Galantamine?
MediHelp also lists interactions of Galantamine with, for example, Memantine-donepezil, Physostigmine, Ponesimod. The full list is on the Galantamine page.
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