Drug interactions
Amiodarone + Galantamine
Severity: Moderate
Amiodarone and Galantamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone may raise galantamine concentrations through CYP2D6 inhibition. Galantamine can cause bradycardia, and amiodarone also slows heart rate, so additive bradycardia and cholinergic adverse effects may occur.
What this interaction means in plain words
Amiodarone and Galantamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiodarone belongs to Cardiovascular; Galantamine belongs to Central Nervous System.
Why it happens
Amiodarone inhibits CYP2D6 metabolism of galantamine, and both drugs have additive bradycardic effects.
What to do
Monitor heart rate and watch for syncope, nausea and vomiting. Reduce the galantamine dose if bradycardia or cholinergic effects develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Other interactions of Galantamine
- Galantamine + Memantine-donepezil Major
- Galantamine + Physostigmine Major
- Galantamine + Ponesimod Major
- Galantamine + Rivastigmine Major
- Amifampridine + Galantamine Moderate
- Amitriptyline + Galantamine Moderate
Frequently asked questions
Can I take Amiodarone with Galantamine?
MediHelp rates the interaction as moderate. Amiodarone and Galantamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amiodarone may raise galantamine concentrations through CYP2D6 inhibition. Galantamine can cause bradycardia, and amiodarone also slows heart rate, so additive bradycardia and cholinergic adverse effects may occur.
How serious is the interaction between Amiodarone and Galantamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and watch for syncope, nausea and vomiting. Reduce the galantamine dose if bradycardia or cholinergic effects develop.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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