Drug interactions
Amoxapine + Lofexidine
Severity: Moderate
Amoxapine and Lofexidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amoxapine adds sedation and hypotension to lofexidine, and tricyclic antidepressants may blunt the effect of central alpha-2 agonists. Amoxapine can also prolong QT, adding to lofexidine's arrhythmic risk.
What this interaction means in plain words
Amoxapine and Lofexidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive sedation and QT prolongation, with possible pharmacodynamic antagonism of alpha-2 agonist effects by tricyclics.
What to do
Monitor ECG, blood pressure and sedation, and watch for reduced lofexidine efficacy for withdrawal symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lofexidine
- Adagrasib + Lofexidine Major
- Alfuzosin + Lofexidine Major
- Amiodarone + Lofexidine Major
- Amisulpride + Lofexidine Major
- Anagrelide + Lofexidine Major
- Apomorphine + Lofexidine Major
Frequently asked questions
Can I take Amoxapine with Lofexidine?
MediHelp rates the interaction as moderate. Amoxapine and Lofexidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amoxapine adds sedation and hypotension to lofexidine, and tricyclic antidepressants may blunt the effect of central alpha-2 agonists. Amoxapine can also prolong QT, adding to lofexidine's arrhythmic risk.
How serious is the interaction between Amoxapine and Lofexidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG, blood pressure and sedation, and watch for reduced lofexidine efficacy for withdrawal symptoms.
What other medicines interact with Lofexidine?
MediHelp also lists interactions of Lofexidine with, for example, Adagrasib, Alfuzosin, Amiodarone. The full list is on the Lofexidine page.
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