Drug interactions
Amoxapine + Morphine
Severity: Moderate
Amoxapine and Morphine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amoxapine adds sedation to morphine and, as a tricyclic with reuptake inhibition, can contribute to serotonergic effects. Combination may cause drowsiness, respiratory depression and rarely serotonin toxicity.
What this interaction means in plain words
Amoxapine and Morphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression plus additive serotonergic activity.
What to do
Start with reduced doses and monitor sedation and respiration. Watch for clonus, agitation and hyperthermia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Morphine
- Alvimopan + Morphine Contraindicated
- Isocarboxazid + Morphine Contraindicated
- Morphine + Olanzapine / samidorphan Contraindicated
- Morphine + Phenelzine Contraindicated
- Morphine + Tranylcypromine Contraindicated
- Alfentanil + Morphine Major
Frequently asked questions
Can I take Amoxapine with Morphine?
MediHelp rates the interaction as moderate. Amoxapine and Morphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amoxapine adds sedation to morphine and, as a tricyclic with reuptake inhibition, can contribute to serotonergic effects. Combination may cause drowsiness, respiratory depression and rarely serotonin toxicity.
How serious is the interaction between Amoxapine and Morphine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with reduced doses and monitor sedation and respiration. Watch for clonus, agitation and hyperthermia.
What other medicines interact with Morphine?
MediHelp also lists interactions of Morphine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Morphine page.
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