Drug interactions
Amoxapine + Oxazepam
Severity: Moderate
Amoxapine and Oxazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amoxapine is a sedating antidepressant, and with oxazepam it can cause additive drowsiness and psychomotor impairment. Falls and impaired driving are the main concerns, especially in older adults.
What this interaction means in plain words
Amoxapine and Oxazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from GABA-A potentiation and antihistaminic/anticholinergic effects of amoxapine.
What to do
Start with lower doses, counsel patients about driving and alcohol, and monitor older patients for sedation and falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxazepam
- Calcium / magnesium / potassium / sodium oxybates + Oxazepam Contraindicated
- Oxazepam + Sodium oxybate Contraindicated
- Alfentanil + Oxazepam Major
- Amobarbital + Oxazepam Major
- Baclofen + Oxazepam Major
- Belladonna and opium + Oxazepam Major
Frequently asked questions
Can I take Amoxapine with Oxazepam?
MediHelp rates the interaction as moderate. Amoxapine and Oxazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amoxapine is a sedating antidepressant, and with oxazepam it can cause additive drowsiness and psychomotor impairment. Falls and impaired driving are the main concerns, especially in older adults.
How serious is the interaction between Amoxapine and Oxazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with lower doses, counsel patients about driving and alcohol, and monitor older patients for sedation and falls.
What other medicines interact with Oxazepam?
MediHelp also lists interactions of Oxazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Oxazepam page.
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