Drug interactions
Amoxapine + Quetiapine
Severity: Major
Amoxapine and Quetiapine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amoxapine has dopamine-blocking properties and can cause extrapyramidal effects, sedation and QT prolongation, all of which add to those of quetiapine. The combination also lowers the seizure threshold and increases anticholinergic and hypotensive effects.
What this interaction means in plain words
Amoxapine and Quetiapine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive D2 blockade, sedation, anticholinergic effects and QT prolongation.
What to do
Avoid the combination if possible, especially in patients with QT risk factors. If used, obtain a baseline and follow-up ECG, check electrolytes and monitor for sedation and movement disorders.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Quetiapine
Frequently asked questions
Can I take Amoxapine with Quetiapine?
MediHelp rates the interaction as major. Amoxapine and Quetiapine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amoxapine has dopamine-blocking properties and can cause extrapyramidal effects, sedation and QT prolongation, all of which add to those of quetiapine. The combination also lowers the seizure threshold and increases anticholinergic and hypotensive effects.
How serious is the interaction between Amoxapine and Quetiapine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible, especially in patients with QT risk factors. If used, obtain a baseline and follow-up ECG, check electrolytes and monitor for sedation and movement disorders.
What other medicines interact with Quetiapine?
MediHelp also lists interactions of Quetiapine with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Quetiapine page.
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