Drug interactions
Amoxapine + Quinine
Severity: Major
Amoxapine and Quinine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amoxapine, a tricyclic-type antidepressant, can prolong QRS and QT intervals, and quinine adds QT prolongation. The combination increases the risk of ventricular arrhythmias including torsades de pointes.
What this interaction means in plain words
Amoxapine and Quinine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Avoid if possible. If used together, obtain a baseline ECG, correct electrolyte abnormalities and monitor the QTc.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Frequently asked questions
Can I take Amoxapine with Quinine?
MediHelp rates the interaction as major. Amoxapine and Quinine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amoxapine, a tricyclic-type antidepressant, can prolong QRS and QT intervals, and quinine adds QT prolongation. The combination increases the risk of ventricular arrhythmias including torsades de pointes.
How serious is the interaction between Amoxapine and Quinine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible. If used together, obtain a baseline ECG, correct electrolyte abnormalities and monitor the QTc.
What other medicines interact with Quinine?
MediHelp also lists interactions of Quinine with, for example, Arsenic trioxide, Dofetilide, Dronedarone. The full list is on the Quinine page.
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