Drug interactions
Dofetilide + Quinine
Severity: Contraindicated
Dofetilide and Quinine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs prolong the QT interval, and quinine may also reduce dofetilide renal elimination by competing for cationic tubular secretion. This raises dofetilide levels and the risk of torsades de pointes, a potentially fatal arrhythmia.
What this interaction means in plain words
Dofetilide and Quinine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Dofetilide belongs to Cardiovascular; Quinine belongs to Anti Parasitic.
Why it happens
Additive QT prolongation combined with competition for renal tubular cationic secretion that increases dofetilide exposure.
What to do
Avoid concurrent use and choose a non-QT-prolonging antimalarial or alternative antiarrhythmic. If quinine is essential, hold dofetilide and use continuous ECG monitoring.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
- Pimozide + Quinine Contraindicated
Other interactions of Dofetilide
- Amiodarone + Dofetilide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
Frequently asked questions
Can I take Dofetilide with Quinine?
MediHelp rates the interaction as contraindicated. Dofetilide and Quinine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs prolong the QT interval, and quinine may also reduce dofetilide renal elimination by competing for cationic tubular secretion. This raises dofetilide levels and the risk of torsades de pointes, a potentially fatal arrhythmia.
How serious is the interaction between Dofetilide and Quinine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and choose a non-QT-prolonging antimalarial or alternative antiarrhythmic. If quinine is essential, hold dofetilide and use continuous ECG monitoring.
What other medicines interact with Quinine?
MediHelp also lists interactions of Quinine with, for example, Arsenic trioxide, Dronedarone, Ibutilide. The full list is on the Quinine page.
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