Drug interactions
Amoxapine + Rasagiline
Severity: Major
Amoxapine and Rasagiline: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antidepressants given with rasagiline have been associated with serious CNS toxicity, including serotonin syndrome with hyperthermia, agitation and autonomic instability. Amoxapine inhibits monoamine reuptake, which adds to the risk.
What this interaction means in plain words
Amoxapine and Rasagiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
MAO-B inhibition (losing selectivity at higher doses) plus reuptake inhibition increases synaptic monoamines.
What to do
Avoid the combination. Allow at least 14 days after stopping rasagiline before starting amoxapine, and an adequate washout of amoxapine before rasagiline.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Rasagiline
- Atomoxetine + Rasagiline Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
- Bupropion + Rasagiline Contraindicated
- Clomipramine + Rasagiline Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
Frequently asked questions
Can I take Amoxapine with Rasagiline?
MediHelp rates the interaction as major. Amoxapine and Rasagiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Antidepressants given with rasagiline have been associated with serious CNS toxicity, including serotonin syndrome with hyperthermia, agitation and autonomic instability. Amoxapine inhibits monoamine reuptake, which adds to the risk.
How serious is the interaction between Amoxapine and Rasagiline?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination. Allow at least 14 days after stopping rasagiline before starting amoxapine, and an adequate washout of amoxapine before rasagiline.
What other medicines interact with Rasagiline?
MediHelp also lists interactions of Rasagiline with, for example, Atomoxetine, Brimonidine, Bupropion-naltrexone. The full list is on the Rasagiline page.
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