Drug interactions
Clomipramine + Rasagiline
Severity: Contraindicated
Clomipramine and Rasagiline: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rasagiline is an MAO-B inhibitor, and combining it with clomipramine carries a risk of serotonin syndrome and hypertensive reactions. Labeling advises a washout period between these drugs.
What this interaction means in plain words
Clomipramine and Rasagiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Clomipramine belongs to Central Nervous System; Rasagiline belongs to Central Nervous System.
Why it happens
MAO inhibition combined with tricyclic serotonin and norepinephrine reuptake blockade increases monoamine levels.
What to do
Do not co-administer; allow at least 14 days after stopping rasagiline before starting clomipramine, and an adequate washout of clomipramine before starting rasagiline.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Rasagiline
- Atomoxetine + Rasagiline Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
- Bupropion + Rasagiline Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
- Deutetrabenazine + Rasagiline Contraindicated
Frequently asked questions
Can I take Clomipramine with Rasagiline?
MediHelp rates the interaction as contraindicated. Clomipramine and Rasagiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Rasagiline is an MAO-B inhibitor, and combining it with clomipramine carries a risk of serotonin syndrome and hypertensive reactions. Labeling advises a washout period between these drugs.
How serious is the interaction between Clomipramine and Rasagiline?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; allow at least 14 days after stopping rasagiline before starting clomipramine, and an adequate washout of clomipramine before starting rasagiline.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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