Drug interactions
Amoxapine + Salmeterol
Severity: Moderate
Amoxapine and Salmeterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amoxapine is a tricyclic-type antidepressant that can potentiate the cardiovascular effects of beta-2 agonists and prolong the QT interval. Combined with salmeterol it may cause tachycardia, palpitations and arrhythmia.
What this interaction means in plain words
Amoxapine and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Blockade of noradrenaline reuptake that enhances sympathomimetic effects, plus additive QT effects.
What to do
Monitor heart rate, rhythm and blood pressure, especially after starting or changing doses. Consider an alternative antidepressant in patients with arrhythmia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Salmeterol
- Ritonavir + Salmeterol Contraindicated
- Salmeterol + Saquinavir Contraindicated
- Amitriptyline + Salmeterol Major
- Arformoterol + Salmeterol Major
- Atazanavir + Salmeterol Major
- Budesonide-formoterol + Salmeterol Major
Frequently asked questions
Can I take Amoxapine with Salmeterol?
MediHelp rates the interaction as moderate. Amoxapine and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amoxapine is a tricyclic-type antidepressant that can potentiate the cardiovascular effects of beta-2 agonists and prolong the QT interval. Combined with salmeterol it may cause tachycardia, palpitations and arrhythmia.
How serious is the interaction between Amoxapine and Salmeterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, rhythm and blood pressure, especially after starting or changing doses. Consider an alternative antidepressant in patients with arrhythmia.
What other medicines interact with Salmeterol?
MediHelp also lists interactions of Salmeterol with, for example, Ritonavir, Saquinavir, Amitriptyline. The full list is on the Salmeterol page.
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