Drug interactions
Amoxapine + Sorafenib
Severity: Moderate
Amoxapine and Sorafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval. Co-administration may add to the risk of torsades de pointes, particularly in patients with cardiac disease or electrolyte disturbance.
What this interaction means in plain words
Amoxapine and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Obtain a baseline ECG and correct potassium and magnesium. Monitor the ECG and consider a less QT-prolonging antidepressant if risk factors are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sorafenib
Frequently asked questions
Can I take Amoxapine with Sorafenib?
MediHelp rates the interaction as moderate. Amoxapine and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval. Co-administration may add to the risk of torsades de pointes, particularly in patients with cardiac disease or electrolyte disturbance.
How serious is the interaction between Amoxapine and Sorafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium and magnesium. Monitor the ECG and consider a less QT-prolonging antidepressant if risk factors are present.
What other medicines interact with Sorafenib?
MediHelp also lists interactions of Sorafenib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Sorafenib page.
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