Drug interactions
Amphotericin b + Budesonide
Severity: Moderate
Amphotericin b and Budesonide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amphotericin B causes renal potassium wasting, and systemic corticosteroids add to potassium loss. Together they can produce clinically significant hypokalemia, with a risk of arrhythmia and muscle weakness. Inhaled or locally acting budesonide contributes less systemically than oral or intravenous steroids.
What this interaction means in plain words
Amphotericin b and Budesonide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amphotericin b belongs to Anti Fungals; Budesonide belongs to Respiratory.
Why it happens
Additive renal potassium loss from amphotericin B-induced tubular damage and corticosteroid mineralocorticoid effect.
What to do
Monitor serum potassium and magnesium regularly and replace deficits promptly. Consider the route and dose of budesonide when judging the risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amphotericin b
- Amphotericin b + Cidofovir Contraindicated
- Adefovir + Amphotericin b Major
- Amikacin + Amphotericin b Major
- Amphotericin b + Arsenic trioxide Major
- Amphotericin b + Capreomycin Major
- Amphotericin b + Cephaloridine Major
Other interactions of Budesonide
Frequently asked questions
Can I take Amphotericin b with Budesonide?
MediHelp rates the interaction as moderate. Amphotericin b and Budesonide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amphotericin B causes renal potassium wasting, and systemic corticosteroids add to potassium loss. Together they can produce clinically significant hypokalemia, with a risk of arrhythmia and muscle weakness. Inhaled or locally acting budesonide contributes less systemically than oral or intravenous steroids.
How serious is the interaction between Amphotericin b and Budesonide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium regularly and replace deficits promptly. Consider the route and dose of budesonide when judging the risk.
What other medicines interact with Amphotericin b?
MediHelp also lists interactions of Amphotericin b with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Amphotericin b page.
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