Drug interactions
Amphotericin b + Capreomycin
Severity: Major
Amphotericin b and Capreomycin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are nephrotoxic, and capreomycin can also cause ototoxicity and electrolyte loss. Together they raise the risk of acute kidney injury and hypokalemia or hypomagnesemia.
What this interaction means in plain words
Amphotericin b and Capreomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive nephrotoxicity through tubular injury and renal electrolyte wasting.
What to do
Avoid concurrent use where an alternative exists. If unavoidable, monitor serum creatinine, potassium and magnesium frequently and replace electrolytes.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amphotericin b
- Amphotericin b + Cidofovir Contraindicated
- Adefovir + Amphotericin b Major
- Amikacin + Amphotericin b Major
- Amphotericin b + Arsenic trioxide Major
- Amphotericin b + Cephaloridine Major
- Amphotericin b + Cisplatin Major
Frequently asked questions
Can I take Amphotericin b with Capreomycin?
MediHelp rates the interaction as major. Amphotericin b and Capreomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs are nephrotoxic, and capreomycin can also cause ototoxicity and electrolyte loss. Together they raise the risk of acute kidney injury and hypokalemia or hypomagnesemia.
How serious is the interaction between Amphotericin b and Capreomycin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where an alternative exists. If unavoidable, monitor serum creatinine, potassium and magnesium frequently and replace electrolytes.
What other medicines interact with Amphotericin b?
MediHelp also lists interactions of Amphotericin b with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Amphotericin b page.
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