Drug interactions
Amphotericin b + Cisplatin
Severity: Major
Amphotericin b and Cisplatin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are nephrotoxic, and each causes renal magnesium and potassium loss. Combined use raises the risk of acute kidney injury, electrolyte depletion and, with cisplatin, ototoxicity. Renal impairment may make cisplatin toxicity worse.
What this interaction means in plain words
Amphotericin b and Cisplatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amphotericin b belongs to Anti Fungals; Cisplatin belongs to Oncology.
Why it happens
Additive tubular nephrotoxicity and renal electrolyte wasting.
What to do
Avoid the combination where possible, or use a lipid amphotericin formulation with adequate hydration. Monitor creatinine, potassium and magnesium frequently and replace electrolytes.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amphotericin b and Cisplatin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Amphotericin b
- Amphotericin b + Cidofovir Contraindicated
- Adefovir + Amphotericin b Major
- Amikacin + Amphotericin b Major
- Amphotericin b + Arsenic trioxide Major
- Amphotericin b + Capreomycin Major
- Amphotericin b + Cephaloridine Major
Other interactions of Cisplatin
- Cidofovir + Cisplatin Contraindicated
- Adefovir + Cisplatin Major
- Adenovirus types 4 and 7 live + Cisplatin Major
- Amikacin + Cisplatin Major
- Amphotericin b deoxycholate + Cisplatin Major
- Bacitracin + Cisplatin Major
Frequently asked questions
Can I take Amphotericin b with Cisplatin?
MediHelp rates the interaction as major. Amphotericin b and Cisplatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs are nephrotoxic, and each causes renal magnesium and potassium loss. Combined use raises the risk of acute kidney injury, electrolyte depletion and, with cisplatin, ototoxicity. Renal impairment may make cisplatin toxicity worse.
How serious is the interaction between Amphotericin b and Cisplatin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, or use a lipid amphotericin formulation with adequate hydration. Monitor creatinine, potassium and magnesium frequently and replace electrolytes.
What other medicines interact with Amphotericin b?
MediHelp also lists interactions of Amphotericin b with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Amphotericin b page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
