Drug interactions
Amphotericin b + Captopril
Severity: Moderate
Amphotericin b and Captopril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amphotericin B may cause hypotension, fluid loss and nephrotoxicity, and captopril lowers blood pressure and glomerular filtration pressure. The combination can increase the risk of hypotension and acute kidney injury.
What this interaction means in plain words
Amphotericin b and Captopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amphotericin b belongs to Anti Fungals; Captopril belongs to Cardiovascular.
Why it happens
Additive hypotensive effects plus ACE inhibitor renal hemodynamic effects superimposed on amphotericin nephrotoxicity.
What to do
Monitor blood pressure, serum creatinine and potassium closely. Hold or reduce captopril if hypotension or worsening renal function occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amphotericin b
- Amphotericin b + Cidofovir Contraindicated
- Adefovir + Amphotericin b Major
- Amikacin + Amphotericin b Major
- Amphotericin b + Arsenic trioxide Major
- Amphotericin b + Capreomycin Major
- Amphotericin b + Cephaloridine Major
Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Frequently asked questions
Can I take Amphotericin b with Captopril?
MediHelp rates the interaction as moderate. Amphotericin b and Captopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amphotericin B may cause hypotension, fluid loss and nephrotoxicity, and captopril lowers blood pressure and glomerular filtration pressure. The combination can increase the risk of hypotension and acute kidney injury.
How serious is the interaction between Amphotericin b and Captopril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and potassium closely. Hold or reduce captopril if hypotension or worsening renal function occurs.
What other medicines interact with Amphotericin b?
MediHelp also lists interactions of Amphotericin b with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Amphotericin b page.
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