Drug interactions
Amphotericin b + Carboplatin
Severity: Moderate
Amphotericin b and Carboplatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can impair renal function, and amphotericin B also causes potassium and magnesium wasting. The combination may therefore increase the risk of kidney injury and electrolyte disturbances. Reduced renal clearance of carboplatin may increase its myelosuppression.
What this interaction means in plain words
Amphotericin b and Carboplatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amphotericin b belongs to Anti Fungals; Carboplatin belongs to Oncology.
Why it happens
Additive nephrotoxicity and renal electrolyte wasting.
What to do
Monitor serum creatinine, potassium and magnesium throughout therapy and replace electrolytes as needed. Recalculate the carboplatin dose from current renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amphotericin b
- Amphotericin b + Cidofovir Contraindicated
- Adefovir + Amphotericin b Major
- Amikacin + Amphotericin b Major
- Amphotericin b + Arsenic trioxide Major
- Amphotericin b + Capreomycin Major
- Amphotericin b + Cephaloridine Major
Other interactions of Carboplatin
Frequently asked questions
Can I take Amphotericin b with Carboplatin?
MediHelp rates the interaction as moderate. Amphotericin b and Carboplatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can impair renal function, and amphotericin B also causes potassium and magnesium wasting. The combination may therefore increase the risk of kidney injury and electrolyte disturbances. Reduced renal clearance of carboplatin may increase its myelosuppression.
How serious is the interaction between Amphotericin b and Carboplatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine, potassium and magnesium throughout therapy and replace electrolytes as needed. Recalculate the carboplatin dose from current renal function.
What other medicines interact with Amphotericin b?
MediHelp also lists interactions of Amphotericin b with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Amphotericin b page.
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