Drug interactions
Amphotericin b + Contrast media
Severity: Major
Amphotericin b and Contrast media: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amphotericin B deoxycholate is nephrotoxic, and iodinated contrast can cause contrast-associated kidney injury. Together they raise the risk of acute kidney injury, particularly in dehydrated patients or those with existing renal impairment.
What this interaction means in plain words
Amphotericin b and Contrast media can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive nephrotoxicity through renal vasoconstriction and tubular injury.
What to do
Delay contrast if feasible or use the lowest dose of iso- or low-osmolar contrast, ensure adequate hydration, and monitor serum creatinine and electrolytes. Consider a lipid amphotericin formulation.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amphotericin b
- Amphotericin b + Cidofovir Contraindicated
- Adefovir + Amphotericin b Major
- Amikacin + Amphotericin b Major
- Amphotericin b + Arsenic trioxide Major
- Amphotericin b + Capreomycin Major
- Amphotericin b + Cephaloridine Major
Frequently asked questions
Can I take Amphotericin b with Contrast media?
MediHelp rates the interaction as major. Amphotericin b and Contrast media can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amphotericin B deoxycholate is nephrotoxic, and iodinated contrast can cause contrast-associated kidney injury. Together they raise the risk of acute kidney injury, particularly in dehydrated patients or those with existing renal impairment.
How serious is the interaction between Amphotericin b and Contrast media?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Delay contrast if feasible or use the lowest dose of iso- or low-osmolar contrast, ensure adequate hydration, and monitor serum creatinine and electrolytes. Consider a lipid amphotericin formulation.
What other medicines interact with Amphotericin b?
MediHelp also lists interactions of Amphotericin b with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Amphotericin b page.
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