Drug interactions
Amphotericin b + Cortisone
Severity: Moderate
Amphotericin b and Cortisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids with mineralocorticoid activity promote potassium excretion, and amphotericin B also causes renal potassium wasting. Combined use can produce more pronounced hypokalemia, raising arrhythmia risk and cardiac glycoside toxicity if relevant.
What this interaction means in plain words
Amphotericin b and Cortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive renal potassium loss from amphotericin tubular effects and corticosteroid mineralocorticoid activity.
What to do
Monitor serum potassium and magnesium regularly and supplement as needed. Use corticosteroids only when clearly indicated during amphotericin therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amphotericin b
- Amphotericin b + Cidofovir Contraindicated
- Adefovir + Amphotericin b Major
- Amikacin + Amphotericin b Major
- Amphotericin b + Arsenic trioxide Major
- Amphotericin b + Capreomycin Major
- Amphotericin b + Cephaloridine Major
Frequently asked questions
Can I take Amphotericin b with Cortisone?
MediHelp rates the interaction as moderate. Amphotericin b and Cortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids with mineralocorticoid activity promote potassium excretion, and amphotericin B also causes renal potassium wasting. Combined use can produce more pronounced hypokalemia, raising arrhythmia risk and cardiac glycoside toxicity if relevant.
How serious is the interaction between Amphotericin b and Cortisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium regularly and supplement as needed. Use corticosteroids only when clearly indicated during amphotericin therapy.
What other medicines interact with Amphotericin b?
MediHelp also lists interactions of Amphotericin b with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Amphotericin b page.
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