Drug interactions
Amphotericin b + Cyclosporine
Severity: Major
Amphotericin b and Cyclosporine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are nephrotoxic, and together they commonly cause additive renal impairment, hypokalemia and hypomagnesemia. In transplant patients this can be difficult to distinguish from rejection.
What this interaction means in plain words
Amphotericin b and Cyclosporine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive nephrotoxicity, with afferent arteriolar vasoconstriction from both agents and direct tubular toxicity from amphotericin B.
What to do
Monitor serum creatinine, potassium and magnesium closely, check cyclosporine trough levels, and ensure hydration. Prefer a liposomal amphotericin formulation and the shortest effective course.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Amphotericin b
- Amphotericin b + Cidofovir Contraindicated
- Adefovir + Amphotericin b Major
- Amikacin + Amphotericin b Major
- Amphotericin b + Arsenic trioxide Major
- Amphotericin b + Capreomycin Major
- Amphotericin b + Cephaloridine Major
Frequently asked questions
Can I take Amphotericin b with Cyclosporine?
MediHelp rates the interaction as major. Amphotericin b and Cyclosporine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs are nephrotoxic, and together they commonly cause additive renal impairment, hypokalemia and hypomagnesemia. In transplant patients this can be difficult to distinguish from rejection.
How serious is the interaction between Amphotericin b and Cyclosporine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine, potassium and magnesium closely, check cyclosporine trough levels, and ensure hydration. Prefer a liposomal amphotericin formulation and the shortest effective course.
What other medicines interact with Amphotericin b?
MediHelp also lists interactions of Amphotericin b with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Amphotericin b page.
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