Drug interactions
Amphotericin b + Dichlorphenamide
Severity: Moderate
Amphotericin b and Dichlorphenamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can lower serum potassium, and dichlorphenamide causes metabolic acidosis which may add to amphotericin-associated renal tubular acidosis. The combination can result in significant hypokalemia and acid-base disturbance.
What this interaction means in plain words
Amphotericin b and Dichlorphenamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amphotericin b belongs to Anti Fungals; Dichlorphenamide belongs to Miscellaneous.
Why it happens
Additive renal potassium wasting and bicarbonate loss from carbonic anhydrase inhibition and amphotericin tubular toxicity.
What to do
Monitor serum potassium and bicarbonate regularly and supplement potassium as needed. Reduce or stop dichlorphenamide if persistent acidosis or hypokalemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amphotericin b
- Amphotericin b + Cidofovir Contraindicated
- Adefovir + Amphotericin b Major
- Amikacin + Amphotericin b Major
- Amphotericin b + Arsenic trioxide Major
- Amphotericin b + Capreomycin Major
- Amphotericin b + Cephaloridine Major
Other interactions of Dichlorphenamide
Frequently asked questions
Can I take Amphotericin b with Dichlorphenamide?
MediHelp rates the interaction as moderate. Amphotericin b and Dichlorphenamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can lower serum potassium, and dichlorphenamide causes metabolic acidosis which may add to amphotericin-associated renal tubular acidosis. The combination can result in significant hypokalemia and acid-base disturbance.
How serious is the interaction between Amphotericin b and Dichlorphenamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and bicarbonate regularly and supplement potassium as needed. Reduce or stop dichlorphenamide if persistent acidosis or hypokalemia develops.
What other medicines interact with Amphotericin b?
MediHelp also lists interactions of Amphotericin b with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Amphotericin b page.
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