Drug interactions
Amphotericin b + Elvitegravir / cobicistat / emtricitabine / tenofovir df
Severity: Major
Amphotericin b and Elvitegravir / cobicistat / emtricitabine / tenofovir df: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amphotericin B is nephrotoxic and tenofovir disoproxil fumarate can injure the proximal tubule, while cobicistat raises serum creatinine by inhibiting tubular secretion. Together the risk of acute kidney injury is increased, and emtricitabine is also renally eliminated.
What this interaction means in plain words
Amphotericin b and Elvitegravir / cobicistat / emtricitabine / tenofovir df can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive nephrotoxicity, with renal tubular effects of tenofovir and cobicistat-related changes in creatinine handling.
What to do
Avoid concurrent use where possible, otherwise monitor serum creatinine, phosphate and urinary protein closely. Stop the regimen if estimated creatinine clearance falls below labeled limits or tubular toxicity develops.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amphotericin b
- Amphotericin b + Cidofovir Contraindicated
- Adefovir + Amphotericin b Major
- Amikacin + Amphotericin b Major
- Amphotericin b + Arsenic trioxide Major
- Amphotericin b + Capreomycin Major
- Amphotericin b + Cephaloridine Major
Frequently asked questions
Can I take Amphotericin b with Elvitegravir / cobicistat / emtricitabine / tenofovir df?
MediHelp rates the interaction as major. Amphotericin b and Elvitegravir / cobicistat / emtricitabine / tenofovir df can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amphotericin B is nephrotoxic and tenofovir disoproxil fumarate can injure the proximal tubule, while cobicistat raises serum creatinine by inhibiting tubular secretion. Together the risk of acute kidney injury is increased, and emtricitabine is also renally eliminated.
How serious is the interaction between Amphotericin b and Elvitegravir / cobicistat / emtricitabine / tenofovir df?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible, otherwise monitor serum creatinine, phosphate and urinary protein closely. Stop the regimen if estimated creatinine clearance falls below labeled limits or tubular toxicity develops.
What other medicines interact with Amphotericin b?
MediHelp also lists interactions of Amphotericin b with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Amphotericin b page.
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