Drug interactions
Amphotericin b + Fludrocortisone
Severity: Major
Amphotericin b and Fludrocortisone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fludrocortisone has strong mineralocorticoid activity that promotes potassium excretion, and amphotericin B independently causes potassium wasting. The combination can lead to significant and sometimes severe hypokalemia.
What this interaction means in plain words
Amphotericin b and Fludrocortisone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amphotericin b belongs to Anti Fungals; Fludrocortisone belongs to Endocrine.
Why it happens
Additive renal potassium loss from mineralocorticoid receptor stimulation and amphotericin B-induced distal tubular leak.
What to do
Monitor potassium and magnesium frequently and give replacement early. Reassess the need for fludrocortisone dose or concurrent use if hypokalemia persists.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amphotericin b
- Amphotericin b + Cidofovir Contraindicated
- Adefovir + Amphotericin b Major
- Amikacin + Amphotericin b Major
- Amphotericin b + Arsenic trioxide Major
- Amphotericin b + Capreomycin Major
- Amphotericin b + Cephaloridine Major
Other interactions of Fludrocortisone
- Fludrocortisone + Mifepristone Contraindicated
- Aldesleukin + Fludrocortisone Major
- Bcg vaccine live + Fludrocortisone Major
- Fludrocortisone + Influenza virus vaccine quadrivalent intranasal Major
- Fludrocortisone + Measles mumps and rubella vaccine live Major
- Fludrocortisone + Measles mumps rubella and varicella vaccine live Major
Frequently asked questions
Can I take Amphotericin b with Fludrocortisone?
MediHelp rates the interaction as major. Amphotericin b and Fludrocortisone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fludrocortisone has strong mineralocorticoid activity that promotes potassium excretion, and amphotericin B independently causes potassium wasting. The combination can lead to significant and sometimes severe hypokalemia.
How serious is the interaction between Amphotericin b and Fludrocortisone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor potassium and magnesium frequently and give replacement early. Reassess the need for fludrocortisone dose or concurrent use if hypokalemia persists.
What other medicines interact with Amphotericin b?
MediHelp also lists interactions of Amphotericin b with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Amphotericin b page.
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