Drug interactions
Amphotericin b + Ganciclovir
Severity: Moderate
Amphotericin b and Ganciclovir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can injure the kidney and suppress bone marrow. Combined use may increase nephrotoxicity and cytopenias, and reduced renal function in turn raises ganciclovir exposure.
What this interaction means in plain words
Amphotericin b and Ganciclovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amphotericin b belongs to Anti Fungals; Ganciclovir belongs to Anti Virals.
Why it happens
Additive nephrotoxicity and myelosuppression, with reduced ganciclovir renal clearance when kidney function declines.
What to do
Monitor serum creatinine and complete blood counts regularly, and adjust the ganciclovir dose to renal function. Ensure adequate hydration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amphotericin b
- Amphotericin b + Cidofovir Contraindicated
- Adefovir + Amphotericin b Major
- Amikacin + Amphotericin b Major
- Amphotericin b + Arsenic trioxide Major
- Amphotericin b + Capreomycin Major
- Amphotericin b + Cephaloridine Major
Other interactions of Ganciclovir
Frequently asked questions
Can I take Amphotericin b with Ganciclovir?
MediHelp rates the interaction as moderate. Amphotericin b and Ganciclovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can injure the kidney and suppress bone marrow. Combined use may increase nephrotoxicity and cytopenias, and reduced renal function in turn raises ganciclovir exposure.
How serious is the interaction between Amphotericin b and Ganciclovir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and complete blood counts regularly, and adjust the ganciclovir dose to renal function. Ensure adequate hydration.
What other medicines interact with Amphotericin b?
MediHelp also lists interactions of Amphotericin b with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Amphotericin b page.
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