Drug interactions
Amphotericin b + Ioversol
Severity: Major
Amphotericin b and Ioversol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ioversol is an iodinated contrast agent that can cause contrast-associated nephropathy, and amphotericin B deoxycholate is nephrotoxic. Combined exposure increases the risk of acute kidney injury, particularly with dehydration or baseline renal impairment.
What this interaction means in plain words
Amphotericin b and Ioversol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive nephrotoxicity through renal vasoconstriction and tubular injury.
What to do
Hydrate the patient, use the lowest effective contrast dose, and monitor serum creatinine for several days afterward. Consider a lipid amphotericin formulation or delay contrast.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amphotericin b
- Amphotericin b + Cidofovir Contraindicated
- Adefovir + Amphotericin b Major
- Amikacin + Amphotericin b Major
- Amphotericin b + Arsenic trioxide Major
- Amphotericin b + Capreomycin Major
- Amphotericin b + Cephaloridine Major
Frequently asked questions
Can I take Amphotericin b with Ioversol?
MediHelp rates the interaction as major. Amphotericin b and Ioversol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ioversol is an iodinated contrast agent that can cause contrast-associated nephropathy, and amphotericin B deoxycholate is nephrotoxic. Combined exposure increases the risk of acute kidney injury, particularly with dehydration or baseline renal impairment.
How serious is the interaction between Amphotericin b and Ioversol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Hydrate the patient, use the lowest effective contrast dose, and monitor serum creatinine for several days afterward. Consider a lipid amphotericin formulation or delay contrast.
What other medicines interact with Amphotericin b?
MediHelp also lists interactions of Amphotericin b with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Amphotericin b page.
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