Drug interactions
Amphotericin b + Magnesium sulfate
Severity: Minor
Amphotericin b and Magnesium sulfate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amphotericin B causes renal magnesium wasting and hypomagnesemia, which can be corrected with intravenous magnesium sulfate. The interaction mainly means magnesium requirements rise during therapy.
What this interaction means in plain words
Amphotericin b and Magnesium sulfate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Amphotericin-induced renal tubular injury increases urinary magnesium excretion.
What to do
Monitor serum magnesium and renal function and replace magnesium as needed, reducing doses if renal function is impaired.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amphotericin b
- Amphotericin b + Cidofovir Contraindicated
- Adefovir + Amphotericin b Major
- Amikacin + Amphotericin b Major
- Amphotericin b + Arsenic trioxide Major
- Amphotericin b + Capreomycin Major
- Amphotericin b + Cephaloridine Major
Frequently asked questions
Can I take Amphotericin b with Magnesium sulfate?
MediHelp rates the interaction as minor. Amphotericin b and Magnesium sulfate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Amphotericin B causes renal magnesium wasting and hypomagnesemia, which can be corrected with intravenous magnesium sulfate. The interaction mainly means magnesium requirements rise during therapy.
How serious is the interaction between Amphotericin b and Magnesium sulfate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum magnesium and renal function and replace magnesium as needed, reducing doses if renal function is impaired.
What other medicines interact with Amphotericin b?
MediHelp also lists interactions of Amphotericin b with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Amphotericin b page.
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