Drug interactions
Amphotericin b + Methoxyflurane
Severity: Major
Amphotericin b and Methoxyflurane: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methoxyflurane is dose-dependently nephrotoxic through fluoride release, and amphotericin B is also nephrotoxic. Combined use can raise the risk of acute kidney injury.
What this interaction means in plain words
Amphotericin b and Methoxyflurane can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive nephrotoxicity from methoxyflurane fluoride metabolites and amphotericin B tubular toxicity.
What to do
Avoid the combination where possible and keep methoxyflurane exposure minimal. Monitor serum creatinine and urine output if both are given.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Amphotericin b
- Amphotericin b + Cidofovir Contraindicated
- Adefovir + Amphotericin b Major
- Amikacin + Amphotericin b Major
- Amphotericin b + Arsenic trioxide Major
- Amphotericin b + Capreomycin Major
- Amphotericin b + Cephaloridine Major
Frequently asked questions
Can I take Amphotericin b with Methoxyflurane?
MediHelp rates the interaction as major. Amphotericin b and Methoxyflurane can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Methoxyflurane is dose-dependently nephrotoxic through fluoride release, and amphotericin B is also nephrotoxic. Combined use can raise the risk of acute kidney injury.
How serious is the interaction between Amphotericin b and Methoxyflurane?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and keep methoxyflurane exposure minimal. Monitor serum creatinine and urine output if both are given.
What other medicines interact with Amphotericin b?
MediHelp also lists interactions of Amphotericin b with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Amphotericin b page.
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