Drug interactions
Amphotericin b + Neomycin po
Severity: Moderate
Amphotericin b and Neomycin po: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral neomycin is poorly absorbed in people with intact gut mucosa, but systemic absorption can occur with inflamed bowel, ulceration or renal impairment, and neomycin is nephrotoxic and ototoxic. With amphotericin B, systemic exposure and additive kidney injury are a concern in those patients.
What this interaction means in plain words
Amphotericin b and Neomycin po can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive nephrotoxicity if absorbed neomycin accumulates alongside amphotericin B tubular toxicity.
What to do
Monitor serum creatinine and electrolytes, and avoid prolonged neomycin use in patients with renal impairment or damaged gut mucosa. Consider a different bowel preparation or antibiotic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amphotericin b
- Amphotericin b + Cidofovir Contraindicated
- Adefovir + Amphotericin b Major
- Amikacin + Amphotericin b Major
- Amphotericin b + Arsenic trioxide Major
- Amphotericin b + Capreomycin Major
- Amphotericin b + Cephaloridine Major
Frequently asked questions
Can I take Amphotericin b with Neomycin po?
MediHelp rates the interaction as moderate. Amphotericin b and Neomycin po can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral neomycin is poorly absorbed in people with intact gut mucosa, but systemic absorption can occur with inflamed bowel, ulceration or renal impairment, and neomycin is nephrotoxic and ototoxic. With amphotericin B, systemic exposure and additive kidney injury are a concern in those patients.
How serious is the interaction between Amphotericin b and Neomycin po?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and electrolytes, and avoid prolonged neomycin use in patients with renal impairment or damaged gut mucosa. Consider a different bowel preparation or antibiotic.
What other medicines interact with Amphotericin b?
MediHelp also lists interactions of Amphotericin b with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Amphotericin b page.
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