Drug interactions
Amphotericin b + Rituximab-hyaluronidase
Severity: Moderate
Amphotericin b and Rituximab-hyaluronidase: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rituximab has been associated with acute kidney injury, particularly with tumor lysis syndrome, and amphotericin B is nephrotoxic. Used together they may increase the risk of renal impairment.
What this interaction means in plain words
Amphotericin b and Rituximab-hyaluronidase can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive nephrotoxic effects.
What to do
Monitor serum creatinine, electrolytes and urine output during co-treatment. Maintain hydration and reassess therapy if renal function worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amphotericin b
- Amphotericin b + Cidofovir Contraindicated
- Adefovir + Amphotericin b Major
- Amikacin + Amphotericin b Major
- Amphotericin b + Arsenic trioxide Major
- Amphotericin b + Capreomycin Major
- Amphotericin b + Cephaloridine Major
Frequently asked questions
Can I take Amphotericin b with Rituximab-hyaluronidase?
MediHelp rates the interaction as moderate. Amphotericin b and Rituximab-hyaluronidase can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rituximab has been associated with acute kidney injury, particularly with tumor lysis syndrome, and amphotericin B is nephrotoxic. Used together they may increase the risk of renal impairment.
How serious is the interaction between Amphotericin b and Rituximab-hyaluronidase?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine, electrolytes and urine output during co-treatment. Maintain hydration and reassess therapy if renal function worsens.
What other medicines interact with Amphotericin b?
MediHelp also lists interactions of Amphotericin b with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Amphotericin b page.
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