Drug interactions
Amphotericin b deoxycholate + Bacitracin-neomycin-polymyxin
Severity: Moderate
Amphotericin b deoxycholate and Bacitracin-neomycin-polymyxin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Polymyxin B and amphotericin B deoxycholate are both nephrotoxic, and polymyxin B can be ototoxic. With topical triple antibiotic products, systemic absorption is usually minimal on intact skin, but can be significant with large wounds, burns or irrigation. In such settings combined renal injury is possible.
What this interaction means in plain words
Amphotericin b deoxycholate and Bacitracin-neomycin-polymyxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive nephrotoxicity through direct renal tubular injury by polymyxin and amphotericin B.
What to do
For topical use on small areas of intact skin no action is needed. When large-area or irrigation use occurs, monitor serum creatinine and electrolytes and consider a non-nephrotoxic alternative.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bacitracin-neomycin-polymyxin
- Allogeneic cultured keratinocytes / fibroblasts in bovine collagen + Bacitracin-neomycin-polymyxin Major
- Atracurium + Bacitracin-neomycin-polymyxin Major
- Bacitracin-neomycin-polymyxin + Capreomycin Major
- Bacitracin-neomycin-polymyxin + Cidofovir Major
- Bacitracin-neomycin-polymyxin + Cisatracurium Major
- Bacitracin-neomycin-polymyxin + Pancuronium Major
Frequently asked questions
Can I take Amphotericin b deoxycholate with Bacitracin-neomycin-polymyxin?
MediHelp rates the interaction as moderate. Amphotericin b deoxycholate and Bacitracin-neomycin-polymyxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Polymyxin B and amphotericin B deoxycholate are both nephrotoxic, and polymyxin B can be ototoxic. With topical triple antibiotic products, systemic absorption is usually minimal on intact skin, but can be significant with large wounds, burns or irrigation. In such settings combined renal injury is possible.
How serious is the interaction between Amphotericin b deoxycholate and Bacitracin-neomycin-polymyxin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: For topical use on small areas of intact skin no action is needed. When large-area or irrigation use occurs, monitor serum creatinine and electrolytes and consider a non-nephrotoxic alternative.
What other medicines interact with Bacitracin-neomycin-polymyxin?
MediHelp also lists interactions of Bacitracin-neomycin-polymyxin with, for example, Allogeneic cultured keratinocytes / fibroblasts in bovine collagen, Atracurium, Capreomycin. The full list is on the Bacitracin-neomycin-polymyxin page.
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