Drug interactions
Bacitracin-neomycin-polymyxin + Cisatracurium
Severity: Major
Bacitracin-neomycin-polymyxin and Cisatracurium: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Polymyxin B and neomycin have intrinsic neuromuscular blocking activity and can potentiate non-depolarizing muscle relaxants. This may prolong paralysis and delay recovery of spontaneous breathing. The risk is mainly with systemic or irrigation use and is low with intact-skin topical use.
What this interaction means in plain words
Bacitracin-neomycin-polymyxin and Cisatracurium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bacitracin-neomycin-polymyxin belongs to Anti Bacterial; Cisatracurium belongs to Musculoskeletal.
Why it happens
Additive pharmacodynamic neuromuscular blockade through reduced presynaptic acetylcholine release and postsynaptic receptor effects.
What to do
Avoid systemic, irrigation or large-area combination antibiotic exposure during neuromuscular blockade where possible. If used, monitor neuromuscular function with train-of-four and ensure ventilatory support is available.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Bacitracin-neomycin-polymyxin
- Allogeneic cultured keratinocytes / fibroblasts in bovine collagen + Bacitracin-neomycin-polymyxin Major
- Atracurium + Bacitracin-neomycin-polymyxin Major
- Bacitracin-neomycin-polymyxin + Capreomycin Major
- Bacitracin-neomycin-polymyxin + Cidofovir Major
- Bacitracin-neomycin-polymyxin + Pancuronium Major
- Bacitracin-neomycin-polymyxin + Rocuronium Major
Other interactions of Cisatracurium
Frequently asked questions
Can I take Bacitracin-neomycin-polymyxin with Cisatracurium?
MediHelp rates the interaction as major. Bacitracin-neomycin-polymyxin and Cisatracurium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Polymyxin B and neomycin have intrinsic neuromuscular blocking activity and can potentiate non-depolarizing muscle relaxants. This may prolong paralysis and delay recovery of spontaneous breathing. The risk is mainly with systemic or irrigation use and is low with intact-skin topical use.
How serious is the interaction between Bacitracin-neomycin-polymyxin and Cisatracurium?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid systemic, irrigation or large-area combination antibiotic exposure during neuromuscular blockade where possible. If used, monitor neuromuscular function with train-of-four and ensure ventilatory support is available.
What other medicines interact with Bacitracin-neomycin-polymyxin?
MediHelp also lists interactions of Bacitracin-neomycin-polymyxin with, for example, Allogeneic cultured keratinocytes / fibroblasts in bovine collagen, Atracurium, Capreomycin. The full list is on the Bacitracin-neomycin-polymyxin page.
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