Drug interactions
Amphotericin b deoxycholate + Colistin
Severity: Major
Amphotericin b deoxycholate and Colistin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are nephrotoxic, and using them together increases the chance of acute kidney injury. Colistin also carries neurotoxic effects, and renal impairment raises its exposure further.
What this interaction means in plain words
Amphotericin b deoxycholate and Colistin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive direct tubular toxicity and renal vasoconstriction.
What to do
Avoid concurrent use if alternatives exist; otherwise monitor serum creatinine and electrolytes frequently, keep patients well hydrated and adjust colistin dose to renal function.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Colistin
- Colistin + Polymyxin b Contraindicated
- Amikacin + Colistin Major
- Amphotericin b + Colistin Major
- Atracurium + Colistin Major
- Bacitracin + Colistin Major
- Capreomycin + Colistin Major
Frequently asked questions
Can I take Amphotericin b deoxycholate with Colistin?
MediHelp rates the interaction as major. Amphotericin b deoxycholate and Colistin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs are nephrotoxic, and using them together increases the chance of acute kidney injury. Colistin also carries neurotoxic effects, and renal impairment raises its exposure further.
How serious is the interaction between Amphotericin b deoxycholate and Colistin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use if alternatives exist; otherwise monitor serum creatinine and electrolytes frequently, keep patients well hydrated and adjust colistin dose to renal function.
What other medicines interact with Colistin?
MediHelp also lists interactions of Colistin with, for example, Polymyxin b, Amikacin, Amphotericin b. The full list is on the Colistin page.
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