Drug interactions
Amphotericin b deoxycholate + Cyclosporin
Severity: Major
Amphotericin b deoxycholate and Cyclosporin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are nephrotoxic, and combined use increases the risk of acute kidney injury and electrolyte disturbance. Amphotericin-induced renal vasoconstriction and tubular injury add to cyclosporine afferent arteriolar constriction. Combination is sometimes unavoidable in transplant patients with serious fungal infection.
What this interaction means in plain words
Amphotericin b deoxycholate and Cyclosporin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive nephrotoxicity through renal vasoconstriction and direct tubular toxicity.
What to do
Avoid if possible, preferring a lipid amphotericin formulation or another antifungal; if used, monitor serum creatinine, potassium and magnesium frequently and check cyclosporine trough levels.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amphotericin b deoxycholate and Cyclosporin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Frequently asked questions
Can I take Amphotericin b deoxycholate with Cyclosporin?
MediHelp rates the interaction as major. Amphotericin b deoxycholate and Cyclosporin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs are nephrotoxic, and combined use increases the risk of acute kidney injury and electrolyte disturbance. Amphotericin-induced renal vasoconstriction and tubular injury add to cyclosporine afferent arteriolar constriction. Combination is sometimes unavoidable in transplant patients with serious fungal infection.
How serious is the interaction between Amphotericin b deoxycholate and Cyclosporin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible, preferring a lipid amphotericin formulation or another antifungal; if used, monitor serum creatinine, potassium and magnesium frequently and check cyclosporine trough levels.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
