Drug interactions
Cyclosporin + Dengue vaccine
Severity: Contraindicated
Cyclosporin and Dengue vaccine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The dengue vaccine is a live attenuated vaccine, so in a patient on cyclosporin the vaccine virus may replicate excessively and cause disease. The immune response may also be inadequate.
What this interaction means in plain words
Cyclosporin and Dengue vaccine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Impaired cell-mediated immunity from calcineurin inhibition allows uncontrolled replication of the live vaccine virus and weakens the response.
What to do
Do not administer the dengue vaccine during cyclosporin therapy. Consider vaccination only after immunosuppression has been stopped for an adequate interval, in consultation with a specialist.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Elagolix Contraindicated
Frequently asked questions
Can I take Cyclosporin with Dengue vaccine?
MediHelp rates the interaction as contraindicated. Cyclosporin and Dengue vaccine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. The dengue vaccine is a live attenuated vaccine, so in a patient on cyclosporin the vaccine virus may replicate excessively and cause disease. The immune response may also be inadequate.
How serious is the interaction between Cyclosporin and Dengue vaccine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not administer the dengue vaccine during cyclosporin therapy. Consider vaccination only after immunosuppression has been stopped for an adequate interval, in consultation with a specialist.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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