Drug interactions
Amphotericin b deoxycholate + Fludrocortisone
Severity: Moderate
Amphotericin b deoxycholate and Fludrocortisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs promote urinary potassium loss, so using them together can cause additive hypokalemia. Low potassium may lead to muscle weakness and cardiac arrhythmias, and amphotericin B also causes renal tubular potassium and magnesium wasting.
What this interaction means in plain words
Amphotericin b deoxycholate and Fludrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive renal potassium wasting: mineralocorticoid effect of fludrocortisone at the distal tubule plus amphotericin-induced tubular damage and potassium leak.
What to do
Monitor serum potassium and magnesium regularly and replace deficits promptly. Consider ECG monitoring if the patient has cardiac disease or other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fludrocortisone
Frequently asked questions
Can I take Amphotericin b deoxycholate with Fludrocortisone?
MediHelp rates the interaction as moderate. Amphotericin b deoxycholate and Fludrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs promote urinary potassium loss, so using them together can cause additive hypokalemia. Low potassium may lead to muscle weakness and cardiac arrhythmias, and amphotericin B also causes renal tubular potassium and magnesium wasting.
How serious is the interaction between Amphotericin b deoxycholate and Fludrocortisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium regularly and replace deficits promptly. Consider ECG monitoring if the patient has cardiac disease or other QT-prolonging drugs.
What other medicines interact with Fludrocortisone?
MediHelp also lists interactions of Fludrocortisone with, for example, Mifepristone, Aldesleukin, Amphotericin b. The full list is on the Fludrocortisone page.
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