Drug interactions
Amphotericin b deoxycholate + Foscarnet
Severity: Major
Amphotericin b deoxycholate and Foscarnet: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are well-known nephrotoxins. Combined use increases the risk of acute kidney injury, and both can cause electrolyte wasting such as hypokalemia and hypomagnesemia. This may need dose reduction or discontinuation.
What this interaction means in plain words
Amphotericin b deoxycholate and Foscarnet can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive nephrotoxicity and renal electrolyte wasting.
What to do
Avoid concurrent use when alternatives exist. If needed, hydrate with saline and monitor serum creatinine, potassium, magnesium, calcium and phosphate frequently.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Foscarnet
- Cidofovir + Foscarnet Contraindicated
- Foscarnet + Pimozide Contraindicated
- Foscarnet + Thioridazine Contraindicated
- Foscarnet + Vandetanib Contraindicated
- Adagrasib + Foscarnet Major
- Adefovir + Foscarnet Major
Frequently asked questions
Can I take Amphotericin b deoxycholate with Foscarnet?
MediHelp rates the interaction as major. Amphotericin b deoxycholate and Foscarnet can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs are well-known nephrotoxins. Combined use increases the risk of acute kidney injury, and both can cause electrolyte wasting such as hypokalemia and hypomagnesemia. This may need dose reduction or discontinuation.
How serious is the interaction between Amphotericin b deoxycholate and Foscarnet?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use when alternatives exist. If needed, hydrate with saline and monitor serum creatinine, potassium, magnesium, calcium and phosphate frequently.
What other medicines interact with Foscarnet?
MediHelp also lists interactions of Foscarnet with, for example, Cidofovir, Pimozide, Thioridazine. The full list is on the Foscarnet page.
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