Drug interactions
Amphotericin b deoxycholate + Ifosfamide
Severity: Major
Amphotericin b deoxycholate and Ifosfamide: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are nephrotoxic, and conventional amphotericin B in particular can worsen renal injury caused by ifosfamide. Electrolyte disturbances such as hypokalemia may also be compounded.
What this interaction means in plain words
Amphotericin b deoxycholate and Ifosfamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive nephrotoxicity with tubular injury from both agents.
What to do
Monitor creatinine, potassium, magnesium and phosphate frequently, and maintain hydration. Consider a lipid amphotericin formulation or alternative antifungal if renal function worsens.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
- Ifosfamide Injection 1g - SmPC sections 4.3/4.5 (names the partner; "– Amphotericin B") — electronic medicines compendium (UK SmPC)
Other interactions of Ifosfamide
- Adenovirus types 4 and 7 live + Ifosfamide Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine live Contraindicated
- Ifosfamide + Measles mumps rubella and varicella vaccine live Contraindicated
- Ifosfamide + Measles vaccine Contraindicated
- Ifosfamide + Rotavirus oral vaccine live Contraindicated
Frequently asked questions
Can I take Amphotericin b deoxycholate with Ifosfamide?
MediHelp rates the interaction as major. Amphotericin b deoxycholate and Ifosfamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs are nephrotoxic, and conventional amphotericin B in particular can worsen renal injury caused by ifosfamide. Electrolyte disturbances such as hypokalemia may also be compounded.
How serious is the interaction between Amphotericin b deoxycholate and Ifosfamide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor creatinine, potassium, magnesium and phosphate frequently, and maintain hydration. Consider a lipid amphotericin formulation or alternative antifungal if renal function worsens.
What other medicines interact with Ifosfamide?
MediHelp also lists interactions of Ifosfamide with, for example, Adenovirus types 4 and 7 live, Measles mumps and rubella vaccine, Measles mumps and rubella vaccine live. The full list is on the Ifosfamide page.
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