Drug interactions
Amphotericin b deoxycholate + Magnesium
Severity: Moderate
Amphotericin b deoxycholate and Magnesium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amphotericin B deoxycholate causes renal tubular injury that leads to urinary magnesium wasting and hypomagnesemia. Low magnesium can aggravate hypokalemia and predispose to arrhythmias, particularly in patients receiving prolonged therapy.
What this interaction means in plain words
Amphotericin b deoxycholate and Magnesium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Amphotericin B damages the renal tubules and increases urinary excretion of magnesium and potassium.
What to do
Monitor serum magnesium and potassium regularly during amphotericin B therapy. Replace magnesium as needed to correct deficits.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Magnesium
- Ciprofloxacin + Magnesium Major
- Magnesium + Pancuronium Major
- Magnesium + Rocuronium Major
- Magnesium + Vecuronium Major
- Amikacin + Magnesium Moderate
- Atracurium + Magnesium Moderate
Frequently asked questions
Can I take Amphotericin b deoxycholate with Magnesium?
MediHelp rates the interaction as moderate. Amphotericin b deoxycholate and Magnesium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amphotericin B deoxycholate causes renal tubular injury that leads to urinary magnesium wasting and hypomagnesemia. Low magnesium can aggravate hypokalemia and predispose to arrhythmias, particularly in patients receiving prolonged therapy.
How serious is the interaction between Amphotericin b deoxycholate and Magnesium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum magnesium and potassium regularly during amphotericin B therapy. Replace magnesium as needed to correct deficits.
What other medicines interact with Magnesium?
MediHelp also lists interactions of Magnesium with, for example, Ciprofloxacin, Pancuronium, Rocuronium. The full list is on the Magnesium page.
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