Drug interactions
Amikacin + Magnesium
Severity: Moderate
Amikacin and Magnesium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aminoglycosides cause renal magnesium wasting, which can lead to hypomagnesemia with prolonged therapy. Low magnesium may then compound electrolyte disturbances such as hypokalemia and hypocalcemia.
What this interaction means in plain words
Amikacin and Magnesium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amikacin belongs to Anti Bacterial; Magnesium belongs to Gastrointestinal Tract.
Why it happens
Aminoglycoside tubular toxicity impairs renal magnesium reabsorption, increasing urinary loss.
What to do
Monitor serum magnesium, potassium and calcium during prolonged aminoglycoside courses. Replace magnesium as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Magnesium
- Ciprofloxacin + Magnesium Major
- Magnesium + Pancuronium Major
- Magnesium + Rocuronium Major
- Magnesium + Vecuronium Major
- Amphotericin b deoxycholate + Magnesium Moderate
- Atracurium + Magnesium Moderate
Other interactions of Amikacin
- Amikacin + Cidofovir Contraindicated
- Adefovir + Amikacin Major
- Amikacin + Amphotericin b Major
- Amikacin + Amphotericin b deoxycholate Major
- Amikacin + Atracurium Major
- Amikacin + Bacitracin Major
Frequently asked questions
Can I take Amikacin with Magnesium?
MediHelp rates the interaction as moderate. Amikacin and Magnesium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aminoglycosides cause renal magnesium wasting, which can lead to hypomagnesemia with prolonged therapy. Low magnesium may then compound electrolyte disturbances such as hypokalemia and hypocalcemia.
How serious is the interaction between Amikacin and Magnesium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum magnesium, potassium and calcium during prolonged aminoglycoside courses. Replace magnesium as needed.
What other medicines interact with Magnesium?
MediHelp also lists interactions of Magnesium with, for example, Ciprofloxacin, Pancuronium, Rocuronium. The full list is on the Magnesium page.
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