Drug interactions
Amphotericin b deoxycholate + Melphalan
Severity: Moderate
Amphotericin b deoxycholate and Melphalan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Conventional amphotericin is the most nephrotoxic formulation and can cause infusion reactions including hypotension and bronchospasm. Combined with melphalan, whose clearance depends partly on renal function, there may be greater renal injury and toxicity.
What this interaction means in plain words
Amphotericin b deoxycholate and Melphalan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Probably additive nephrotoxicity; no specific mechanism is established for the other effects.
What to do
Monitor serum creatinine, electrolytes and urine output, and watch infusions for hypotension or bronchospasm. Hydrate adequately and reduce the melphalan dose if renal function worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Melphalan
- Adenovirus types 4 and 7 live + Melphalan Contraindicated
- Bcg vaccine live + Melphalan Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Melphalan Contraindicated
- Measles mumps and rubella vaccine live + Melphalan Contraindicated
- Measles mumps and rubella vaccine + Melphalan Contraindicated
- Measles mumps rubella and varicella vaccine live + Melphalan Contraindicated
Frequently asked questions
Can I take Amphotericin b deoxycholate with Melphalan?
MediHelp rates the interaction as moderate. Amphotericin b deoxycholate and Melphalan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Conventional amphotericin is the most nephrotoxic formulation and can cause infusion reactions including hypotension and bronchospasm. Combined with melphalan, whose clearance depends partly on renal function, there may be greater renal injury and toxicity.
How serious is the interaction between Amphotericin b deoxycholate and Melphalan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine, electrolytes and urine output, and watch infusions for hypotension or bronchospasm. Hydrate adequately and reduce the melphalan dose if renal function worsens.
What other medicines interact with Melphalan?
MediHelp also lists interactions of Melphalan with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Melphalan page.
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