Drug interactions
Amphotericin b deoxycholate + Rituximab
Severity: Moderate
Amphotericin b deoxycholate and Rituximab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amphotericin B deoxycholate is nephrotoxic, and rituximab infusions can occasionally cause acute kidney injury, mainly via tumor lysis or cytokine release. The combination may increase the risk of renal impairment.
What this interaction means in plain words
Amphotericin b deoxycholate and Rituximab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive nephrotoxic potential: direct tubular toxicity from amphotericin plus rituximab-related tumor lysis or infusion reactions.
What to do
Monitor serum creatinine and electrolytes during treatment. Ensure hydration and consider a lipid amphotericin formulation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rituximab
Frequently asked questions
Can I take Amphotericin b deoxycholate with Rituximab?
MediHelp rates the interaction as moderate. Amphotericin b deoxycholate and Rituximab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amphotericin B deoxycholate is nephrotoxic, and rituximab infusions can occasionally cause acute kidney injury, mainly via tumor lysis or cytokine release. The combination may increase the risk of renal impairment.
How serious is the interaction between Amphotericin b deoxycholate and Rituximab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and electrolytes during treatment. Ensure hydration and consider a lipid amphotericin formulation.
What other medicines interact with Rituximab?
MediHelp also lists interactions of Rituximab with, for example, Adenovirus types 4 and 7 live, Baricitinib, Certolizumab pegol. The full list is on the Rituximab page.
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