Drug interactions
Etrasimod + Rituximab
Severity: Major
Etrasimod and Rituximab: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etrasimod lowers circulating lymphocyte counts by sequestering them in lymphoid tissue, and rituximab depletes B cells. Together they may cause additive immunosuppression and a higher risk of serious infection, and this has not been studied.
What this interaction means in plain words
Etrasimod and Rituximab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Etrasimod belongs to Gastrointestinal Tract; Rituximab belongs to Musculoskeletal.
Why it happens
Additive immunosuppression from S1P receptor modulation (lymphocyte sequestration) and anti-CD20 B-cell depletion.
What to do
Avoid combining them where possible, and allow for the prolonged effect of each drug when switching. If combined, monitor lymphocyte counts and watch closely for infection.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Rituximab
Other interactions of Etrasimod
- Abatacept + Etrasimod Major
- Amiodarone + Etrasimod Major
- Anagrelide + Etrasimod Major
- Anakinra + Etrasimod Major
- Anti-thymocyte + Etrasimod Major
- Asenapine + Etrasimod Major
Frequently asked questions
Can I take Etrasimod with Rituximab?
MediHelp rates the interaction as major. Etrasimod and Rituximab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Etrasimod lowers circulating lymphocyte counts by sequestering them in lymphoid tissue, and rituximab depletes B cells. Together they may cause additive immunosuppression and a higher risk of serious infection, and this has not been studied.
How serious is the interaction between Etrasimod and Rituximab?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining them where possible, and allow for the prolonged effect of each drug when switching. If combined, monitor lymphocyte counts and watch closely for infection.
What other medicines interact with Rituximab?
MediHelp also lists interactions of Rituximab with, for example, Adenovirus types 4 and 7 live, Baricitinib, Certolizumab pegol. The full list is on the Rituximab page.
Full monographs, dosing and an interaction checker in the MediHelp app
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