Drug interactions
Amphotericin b deoxycholate + Rocuronium
Severity: Moderate
Amphotericin b deoxycholate and Rocuronium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amphotericin B deoxycholate can cause hypokalemia and hypomagnesemia, which can enhance and prolong the effect of non-depolarizing neuromuscular blockers such as rocuronium. This may lead to delayed recovery of muscle strength.
What this interaction means in plain words
Amphotericin b deoxycholate and Rocuronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Electrolyte disturbances (low potassium and magnesium) from amphotericin B-induced renal wasting alter neuromuscular transmission and potentiate blockade.
What to do
Check and correct potassium and magnesium before and during anesthesia. Monitor neuromuscular function with train-of-four and titrate rocuronium to effect.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rocuronium
Frequently asked questions
Can I take Amphotericin b deoxycholate with Rocuronium?
MediHelp rates the interaction as moderate. Amphotericin b deoxycholate and Rocuronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amphotericin B deoxycholate can cause hypokalemia and hypomagnesemia, which can enhance and prolong the effect of non-depolarizing neuromuscular blockers such as rocuronium. This may lead to delayed recovery of muscle strength.
How serious is the interaction between Amphotericin b deoxycholate and Rocuronium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check and correct potassium and magnesium before and during anesthesia. Monitor neuromuscular function with train-of-four and titrate rocuronium to effect.
What other medicines interact with Rocuronium?
MediHelp also lists interactions of Rocuronium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Capreomycin. The full list is on the Rocuronium page.
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